富马酸普鲁斯卡林

Proscaline Fumarate – Scientific Product Documentation

🔬Chemical Specifications

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Core parameters:

• IUPAC名称 : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• 分子式 ：C₁₃H₂₁NO₃·C₄H₄O₄

• 分子量 : 339.36 g/mol

• 纯度 : ≥98% (HPLC-UV at 254 nm)

• 形式 : White crystalline powder

• Melting point : 172-174°C (decomposes)

• 溶解度 ：15 mg/ml 溶于水，30 mg/ml 溶于温乙醇

🧫研究应用

1. 受体结合研究 :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. 代谢途径分析 :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Toxicological data :

   • LD₅₀ (rat, oral): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Side effect spectrum :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Critical Interactions :

   • Dangerous : MAO inhibitors, sympathomimetics

   • Risky : Serotonergic agents, vasopressors

📉稳定性数据

• 保质期 : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Mass spectrum : [M+H]⁺ 240.2 m/z

• UV absorption : λmax 282 nm (ε = 4200)

❓Research-oriented FAQ

Q1: What is the mechanism of action?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Research limitations

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.