{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23358"},"modified":"2025-10-30T10:10:50","modified_gmt":"2025-10-30T10:10:50","slug":"dmxe-40-mg-peleti-deoksimetoksetamina","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/sl\/trgovina\/arilcikloheksilamin\/dmxe-40-mg-peleti-deoksimetoksetamina\/","title":{"rendered":"DMXE 40 mg peleti (deoksimetoksetamin)"},"content":{"rendered":"

DMXE (deoksimetoksetamin) 40 mg peleti \u2013 znanstvena dokumentacija izdelka<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cKemijske specifikacije<\/span><\/span><\/strong><\/h4>\n

DMXE (2\u2032-okso-PCE-d10) je raziskovalna kemikalija, ki spada v razred arilcikloheksilaminov in je strukturno sorodna MXE (metoksetaminu) in ketaminu. Te pelete so zasnovane za natan\u010dne znanstvene raziskave.<\/span><\/span><\/p>\n

Osnovni parametri:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    Ime IUPAC<\/span><\/span><\/strong> 2-(3,4-dimetilfenil)-2-(etilamino)cikloheksanon<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekulska formula<\/span><\/span><\/strong> C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekulska masa<\/span><\/span><\/strong> : 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u010cistost<\/span><\/span><\/strong> : \u226598% (analiza GC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Oblika<\/span><\/span><\/strong> Okrogli peleti s premerom 4 mm<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Barva<\/span><\/span><\/strong> Svetlo be\u017e do bela<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Topnost<\/span><\/span><\/strong> 15 mg\/ml v vodi (pri 25 \u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaZnanstvene aplikacije<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Nevrofarmakolo\u0161ke raziskave<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

        \n
      • \n

        \u0160tudije antagonizma receptorjev NMDA<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Interakcijski testi sigma-1 receptorjev<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Vedenjska nevroznanost<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

          \n
        • \n

          Vpliv na u\u010dno vedenje pri laboratorijskih \u017eivalih<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Od odmerka odvisni disociativni u\u010dinki<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Psihofarmakologija<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

            \n
          • \n

            Primerjalne \u0161tudije s sorodnimi disociativi<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Raziskave nevroplasti\u010dnih u\u010dinkov<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fPriporo\u010deni raziskovalni protokoli<\/span><\/span><\/strong><\/h4>\n

            Eksperimentalne smernice:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/span><\/span><\/th>\nOdmerjanje<\/span><\/span><\/th>\nPogostost<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10\u201350 \u03bcM<\/span><\/span><\/td>\nEnkratna izpostavljenost<\/span><\/span><\/td>\n<\/tr>\n
            Majhni glodalci<\/span><\/span><\/td>\n5\u201320 mg\/kg<\/span><\/span><\/td>\n1x\/dan (najve\u010d 3 dni)<\/span><\/span><\/td>\n<\/tr>\n
            Primati<\/span><\/span><\/td>\n1\u20135 mg\/kg<\/span><\/span><\/td>\nEnkratni odmerek<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Opomba: Nelinearna farmakokinetika nad 25 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fVarnostni profil in obvladovanje tveganj<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toksikolo\u0161ki podatki<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (podgana, oralno): 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

              • \n

                NOAEL: 5 mg\/kg\/dan (7-dnevna \u0161tudija)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Spekter stranskih u\u010dinkov<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                  \n
                • \n

                  <10 mg: Subtilni vedenjski u\u010dinki<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  10\u201330 mg: Motori\u010dna neusklajenost<\/span><\/span><\/p>\n<\/li>\n

                • \n
                  \n

                  30 mg: Mo\u017ena depresija dihanja<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kriti\u010dne interakcije<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                    \n
                  • \n

                    Nevarno<\/span><\/span><\/strong> Opioidi, GABA-ergi\u010dni pripravki<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Tvegano<\/span><\/span><\/strong> Stimulansi, zaviralci MAO<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaNadzor kakovosti in analiti\u010dni podatki<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistost HPLC<\/span><\/span><\/strong> 98,5% (kolona C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Enakomernost<\/span><\/span><\/strong> Odstopanje te\u017ee \u00b15% (n=20 peletov)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u010cas razpadanja<\/span><\/span><\/strong> <15 minut (ob hkratnem delovanju \u017eelod\u010dnega soka)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Podatki o stabilnosti<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        Rok uporabnosti: 24 mesecev pri 15\u201325 \u00b0C<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Ob\u010dutljivost na vlago: <0,5% pridobivanje te\u017ee (93% relativna vla\u017enost)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Pogosto zastavljena raziskovalna vpra\u0161anja<\/span><\/span><\/strong><\/h4>\n

                        V1: Kak\u0161en je mehanizem delovanja?<\/span><\/span><\/strong>
                        \n A: Primarni antagonizem receptorjev NMDA s sekundarnim zaviranjem ponovnega privzema dopamina.<\/span><\/span><\/p>\n

                        V2: Kak\u0161na je u\u010dinkovitost v primerjavi s ketaminom?<\/span><\/span><\/strong>
                        \n A: ~0,6-krat ve\u010dja mo\u010d kot ketamin, vendar dalj\u0161a razpolovna doba (4-6 ur).<\/span><\/span><\/p>\n

                        V3: Ali obstajajo kak\u0161na nevrotoksi\u010dna tveganja?<\/span><\/span><\/strong>
                        \n A: Olneyjeve lezije niso bile opa\u017eene pri odmerku <50 mg\/kg (\u0161tudija na podganah).<\/span><\/span><\/p>\n

                        V4: Kateri je optimalni na\u010din shranjevanja?<\/span><\/span><\/strong>
                        \n A: V originalni embala\u017ei pri temperaturi 15\u201325 \u00b0C, za\u0161\u010diteno pred vlago.<\/span><\/span><\/p>\n

                        \ud83d\udcccOmejitve raziskav<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Omejeni podatki o kroni\u010dni uporabi<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Neznani u\u010dinki na prenos glutamata<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Spremenljiva biotransformacija med vrstami<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dZaklju\u010dek za raziskovalce<\/span><\/span><\/strong><\/h4>\n

                          DMXE 40 mg pelete ponujajo standardizirano formulacijo za natan\u010dne disociativne raziskave, z doslednim odmerjanjem in dobro stabilnostjo. Oblika peletov omogo\u010da kvantitativno dajanje v \u0161tudijah na \u017eivalih.<\/span><\/span><\/p>\n

                          Znanstveno opozorilo: Ta izdelek je namenjen izklju\u010dno raziskavam in vitro in odobrenim predklini\u010dnim \u0161tudijam. Ni za uporabo pri ljudeh. Vsi poskusi morajo biti v skladu z veljavnimi eti\u010dnimi smernicami in lokalnimi predpisi. Upo\u0161tevajte poseben status psihoaktivnih snovi za raziskave v va\u0161i jurisdikciji.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Funkcije DMXE<\/span><\/span><\/span><\/span><\/h3>\n

                          Sinonim:<\/span><\/span><\/span><\/span><\/strong> Deoksimetoksilamin hidroklorid <\/span><\/span><\/span><\/span>
                          \n\u0160tevilka CAS:<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nFormula:<\/span><\/span><\/span><\/span><\/strong> 5-dehidro-1,3-kinodimetan <\/span><\/span><\/span><\/span>
                          \nMolska masa:<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \n\u010cistost:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28509,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28745,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product\/23358\/revisions\/28745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/media\/28509"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/sl\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}