Fumarato de proscalina

Proscaline Fumarate – Scientific Product Documentation

🔬Especificações Químicas

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Parâmetros principais:

• Nome IUPAC : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Fórmula molecular : C₁₃H₂₁NO₃ · C₄H₄O₄

• Peso molecular : 339.36 g/mol

• Pureza : ≥98% (HPLC-UV at 254 nm)

• Forma : White crystalline powder

• Melting point : 172-174°C (decomposes)

• Solubilidade : 15 mg/ml em água, 30 mg/ml em etanol morno

🧫Aplicações de pesquisa

1. Estudos de ligação do receptor :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Análise da via metabólica :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Dados toxicológicos :

   • DL₅₀ (rato, via oral): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Espectro de efeitos colaterais :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Interações Críticas :

   • Perigoso : MAO inhibitors, sympathomimetics

   • Arriscado : Serotonergic agents, vasopressors

📉Dados de estabilidade

• Prazo de validade : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Mass spectrum : [M+H]⁺ 240.2 m/z

• UV absorption : λmáx 282 nm (ε = 4200)

❓Research-oriented FAQ

Q1: Qual é o mecanismo de ação?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Limitações da pesquisa

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.