{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23378"},"modified":"2025-06-30T11:38:45","modified_gmt":"2025-06-30T11:38:45","slug":"eskalinhydroklorid","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/is\/bud\/naestum-bannad\/eskalinhydroklorid\/","title":{"rendered":"Eskal\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0"},"content":{"rendered":"

Eskal\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 \u2013 V\u00edsindaleg v\u00f6ruuppl\u00fdsingar<\/strong><\/h3>\n

\ud83d\udd2c Efnafr\u00e6\u00f0ilegar uppl\u00fdsingar<\/strong><\/h4>\n

Eskal\u00edn (4-etox\u00fd-3,5-d\u00edmetox\u00fdfenet\u00fdlam\u00edn) h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 er h\u00e1lftilb\u00fain fenet\u00fdlam\u00edn aflei\u00f0a sem er byggingarlega skyld meskal\u00edni. \u00deetta ranns\u00f3knarefni er veri\u00f0 a\u00f0 rannsaka vegna \u00e1hugaver\u00f0rar lyfjafr\u00e6\u00f0ilegrar eiginleika \u00feess.<\/p>\n

Kjarnabreytur:<\/em><\/p>\n

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    IUPAC-heiti<\/strong>2-(4-etox\u00fd-3,5-d\u00edmetox\u00fdfen\u00fdl)etan-1-am\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0<\/p>\n<\/li>\n

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    Sameindaform\u00fala<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

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    M\u00f3l\u00feungi<\/strong>: 261,75 g\/m\u00f3l<\/p>\n<\/li>\n

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    Hreinleiki<\/strong>: \u226598% (HPLC-UV vi\u00f0 280 nm)<\/p>\n<\/li>\n

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    Ey\u00f0ubla\u00f0<\/strong>Hv\u00edtt kristalla\u00f0 duft<\/p>\n<\/li>\n

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    Br\u00e6\u00f0slumark<\/strong>: 243-245\u00b0C (brotnar ni\u00f0ur)<\/p>\n<\/li>\n

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    Leysni<\/strong>50 mg\/ml \u00ed vatni, 30 mg\/ml \u00ed metan\u00f3li<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea V\u00edsindaleg notkun<\/strong><\/h4>\n
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    1. \n

      Taugalyfjafr\u00e6\u00f0ilegar ranns\u00f3knir<\/strong>:<\/p>\n

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        Ranns\u00f3knir \u00e1 bindingu vi\u00f0 5-HT\u2082A vi\u00f0taka (Ki = 120 nM)<\/p>\n<\/li>\n

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        Samanbur\u00f0arranns\u00f3knir \u00e1 meskal\u00edni og \u00f6\u00f0rum fenet\u00fdlam\u00ednum<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Atferlisranns\u00f3knir<\/strong>:<\/p>\n

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          \u00c1hrif \u00e1 heg\u00f0un d\u00fdra \u00ed st\u00fdr\u00f0um a\u00f0st\u00e6\u00f0um<\/p>\n<\/li>\n

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          Skammta-sv\u00f6runartengsl \u00ed spend\u00fdral\u00edk\u00f6num<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Ranns\u00f3knir \u00e1 efnaskiptum<\/strong>:<\/p>\n

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            Ranns\u00f3kn \u00e1 hvarfhra\u00f0a O-afalk\u00fdleringar<\/p>\n<\/li>\n

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            CYP2D6 milliverkanapr\u00f3f\u00edl<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f R\u00e1\u00f0lag\u00f0ir skammtar fyrir ranns\u00f3knir<\/strong><\/h4>\n

            Tilraunalei\u00f0beiningar:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Fyrirmynd<\/th>\nSkammtar<\/th>\nStj\u00f3rns\u00fdsluvegur<\/th>\n<\/tr>\n<\/thead>\n
            \u00cd tilraunaglasi<\/td>\n10-100 m\u00edkr\u00f3m\u00f3l<\/td>\nFrumur\u00e6ktunarmi\u00f0ill<\/td>\n<\/tr>\n
            Sm\u00e1d\u00fdr<\/td>\n1-5 mg\/kg<\/td>\n\u00cd kvi\u00f0arholi<\/td>\n<\/tr>\n
            Pr\u00edmatar<\/td>\n0,2-1 mg\/kg<\/td>\nMunnlegt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Athugi\u00f0: Skammtah\u00e1\u00f0 \u00e1hrif yfir 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f \u00d6ryggis\u00fe\u00e6ttir og \u00e1h\u00e6tta<\/strong><\/h4>\n
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            1. \n

              Eiturefnafr\u00e6\u00f0ilegar uppl\u00fdsingar<\/strong>:<\/p>\n

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                LD\u2085\u2080 (m\u00fas, \u00ed bl\u00e1\u00e6\u00f0): 185 mg\/kg<\/p>\n<\/li>\n

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                NOAEL: 0,75 mg\/kg\/dag (28 daga ranns\u00f3kn)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Aukaverkanir<\/strong>:<\/p>\n

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                  <2 mg\/kg: L\u00e1gmarks l\u00edfe\u00f0lisfr\u00e6\u00f0ileg \u00e1hrif<\/p>\n<\/li>\n

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                  2-6 mg\/kg: Skynjunarst\u00fdring<\/p>\n<\/li>\n

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                  \n

                  6 mg\/kg: Hugsanleg \u00e1hrif \u00e1 bl\u00f3\u00f0fl\u00e6\u00f0i<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Mikilv\u00e6g samskipti<\/strong>:<\/p>\n

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                    H\u00e6ttulegt<\/strong>MAO-hemlar, ser\u00f3t\u00f3n\u00ednvirk lyf<\/p>\n<\/li>\n

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                    \u00c1h\u00e6ttusamt<\/strong>\u00c6\u00f0asamdr\u00e1ttarlyf, ge\u00f0rofslyf<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca G\u00e6\u00f0aeftirlit og greiningarg\u00f6gn<\/strong><\/h4>\n
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                      HPLC hreinleiki<\/strong>98,2% (C18 s\u00fala, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

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                      Leifar af leysiefnum<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

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                      St\u00f6\u00f0ugleikag\u00f6gn<\/strong>:<\/p>\n

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                        Geymslu\u00feol: 24 m\u00e1nu\u00f0ir vi\u00f0 -20\u00b0C<\/p>\n<\/li>\n

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                        Herbergishitastig: 6 m\u00e1nu\u00f0ir (undir argoni)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Algengar ranns\u00f3knarspurningar<\/strong><\/h4>\n

                        Spurning 1: Hver er verkunarh\u00e1ttur?<\/strong>
                        \nA: A\u00f0alverkun sem 5-HT\u2082A vi\u00f0taka\u00f6rvi me\u00f0 aukaverkunum \u00e1 d\u00f3pam\u00ednkerfi.<\/p>\n

                        Spurning 2: Hvernig ber virknin saman vi\u00f0 meskal\u00edn?<\/strong>
                        \nA: Um \u00fea\u00f0 bil 1,5 sinnum meiri s\u00e6kni \u00ed vi\u00f0taka en lengri verkunart\u00edmi (8-10 klukkustundir).<\/p>\n

                        Spurning 3: Hverjar eru bestu geymsluskilyr\u00f0in?<\/strong>
                        \nA: \u00cd gulbr\u00fanum hettugl\u00f6sum undir \u00f3virku gasi vi\u00f0 -20\u00b0C.<\/p>\n

                        Spurning 4: Eru einhverjar \u00e1h\u00e6ttur \u00e1 erf\u00f0aeiturverkunum?<\/strong>
                        \nA: Ames pr\u00f3f neikv\u00e6tt vi\u00f0 <1 mM, en takmarka\u00f0ar uppl\u00fdsingar um litningapr\u00f3f.<\/p>\n

                        \ud83d\udccc Takmarkanir ranns\u00f3kna<\/strong><\/h4>\n
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                          Takmarka\u00f0ar uppl\u00fdsingar um langvarandi \u00fatsetningu<\/p>\n<\/li>\n

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                          \u00d3\u00feekkt \u00e1hrif \u00e1 taugam\u00f3tun<\/p>\n<\/li>\n

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                          Breytileg efnaskipti milli tegunda<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Ni\u00f0ursta\u00f0a fyrir v\u00edsindamenn<\/strong><\/h4>\n

                          Eskal\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 b\u00fd\u00f0ur upp \u00e1 ver\u00f0m\u00e6t t\u00e6kif\u00e6ri til samanbur\u00f0arranns\u00f3kna \u00e1 ser\u00f3t\u00f3n\u00edni, me\u00f0 einstakri bl\u00f6ndu af st\u00f6\u00f0ugleika og endingu. H\u00fddr\u00f3kl\u00f3r\u00ed\u00f0formi\u00f0 tryggir fram\u00farskarandi leysni fyrir ranns\u00f3knarstofunotkun.<\/p>\n

                          Mikilv\u00e6g fyrirvari: \u00deessi vara er eing\u00f6ngu \u00e6tlu\u00f0 til v\u00edsindaranns\u00f3kna \u00ed vi\u00f0urkenndum ranns\u00f3knarstofum. Ekki til notkunar \u00e1 m\u00f6nnum e\u00f0a til greiningar. Allar tilraunir ver\u00f0a a\u00f0 vera framkv\u00e6mdar \u00ed samr\u00e6mi vi\u00f0 gildandi reglur og si\u00f0areglur.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Eskal\u00edn h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 eiginleikar<\/span><\/h3>\n

                          Samheiti:<\/strong> 3,5-d\u00edmetox\u00fd-4-etox\u00fdfenet\u00fdlam\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0
                          \nCAS-n\u00famer:<\/strong> 39201-82-6
                          \nForm\u00fala:<\/strong> 2-{3,5-d\u00edmetox\u00fd-4-et\u00fdlox\u00fdfen\u00fdl}etan-1-am\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0
                          \nM\u00f3lmassi:<\/strong> 261,8 g\/m\u00f3l
                          \nHreinleiki:<\/strong> >97%<\/p>","protected":false},"featured_media":20228,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/media\/20228"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/is\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}