{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23358"},"modified":"2025-10-30T10:10:50","modified_gmt":"2025-10-30T10:10:50","slug":"dmxe-40-mg-pelete-deoksimetoksetamina","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/hr\/ducan\/arilcikloheksilamin\/dmxe-40-mg-pelete-deoksimetoksetamina\/","title":{"rendered":"DMXE 40 mg pelete (deoksimetoksetamin)"},"content":{"rendered":"

DMXE (deoksimetoksetamin) 40 mg pelete \u2013 Znanstvena dokumentacija o proizvodu<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cKemijske specifikacije<\/span><\/span><\/strong><\/h4>\n

DMXE (2\u2032-okso-PCE-d10) je istra\u017eiva\u010dka kemikalija koja pripada klasi arilcikloheksilamina, strukturno srodna MXE (metoksetaminu) i ketaminu. Ove pelete su formulirane za precizna znanstvena istra\u017eivanja.<\/span><\/span><\/p>\n

Osnovni parametri:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    Naziv po IUPAC-u<\/span><\/span><\/strong> 2-(3,4-dimetilfenil)-2-(etilamino)cikloheksanon<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekularna formula<\/span><\/span><\/strong> C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekularna te\u017eina<\/span><\/span><\/strong> : 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u010cisto\u0107a<\/span><\/span><\/strong> : \u226598% (GC-MS analiza)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Oblik<\/span><\/span><\/strong> Okrugle pelete promjera 4 mm<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Boja<\/span><\/span><\/strong> Svijetlo be\u017e do bijele<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Topljivost<\/span><\/span><\/strong> 15 mg\/ml u vodi (na 25\u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaZnanstvene primjene<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakolo\u0161ka istra\u017eivanja<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

        \n
      • \n

        Studije antagonizma NMDA receptora<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Testovi interakcije sigma-1 receptora<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Bihevioralna neuroznanost<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

          \n
        • \n

          Utjecaji na pona\u0161anje u\u010denja kod laboratorijskih \u017eivotinja<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Disocijativni u\u010dinci ovisni o dozi<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Psihofarmakologija<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

            \n
          • \n

            Komparativne studije sa srodnim disocijativima<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Istra\u017eivanje neuroplasti\u010dnih u\u010dinaka<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fPreporu\u010deni istra\u017eiva\u010dki protokoli<\/span><\/span><\/strong><\/h4>\n

            Eksperimentalne smjernice:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/span><\/span><\/th>\nDoziranje<\/span><\/span><\/th>\nFrekvencija<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10-50 \u03bcM<\/span><\/span><\/td>\nJednokratna ekspozicija<\/span><\/span><\/td>\n<\/tr>\n
            Mali glodavci<\/span><\/span><\/td>\n5-20 mg\/kg<\/span><\/span><\/td>\n1x\/dan (maksimalno 3 dana)<\/span><\/span><\/td>\n<\/tr>\n
            Primati<\/span><\/span><\/td>\n1-5 mg\/kg<\/span><\/span><\/td>\nJedna doza<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Napomena: Nelinearna farmakokinetika iznad 25 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fSigurnosni profil i upravljanje rizicima<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toksikolo\u0161ki podaci<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (\u0161takor, oralno): 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

              • \n

                NOAEL: 5 mg\/kg\/dan (7-dnevna studija)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Spektar nuspojava<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                  \n
                • \n

                  <10 mg: Suptilni u\u010dinci na pona\u0161anje<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  10-30 mg: Motorna nekoordiniranost<\/span><\/span><\/p>\n<\/li>\n

                • \n
                  \n

                  30 mg: Mogu\u0107a respiratorna depresija<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kriti\u010dne interakcije<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                    \n
                  • \n

                    Opasno<\/span><\/span><\/strong> Opioidi, GABA-ergici<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Riskantno<\/span><\/span><\/strong> Stimulansi, MAO inhibitori<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaKontrola kvalitete i analiti\u010dki podaci<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC \u010disto\u0107a<\/span><\/span><\/strong> 98,5% (kolona C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Ujedna\u010denost<\/span><\/span><\/strong> Odstupanje te\u017eine \u00b15% (n=20 peleta)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Vrijeme raspadanja<\/span><\/span><\/strong> <15 minuta (uz istovremeno djelovanje \u017eelu\u010danog soka)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Podaci o stabilnosti<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        Rok trajanja: 24 mjeseca na 15-25\u00b0C<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Osjetljivost na vlagu: <0,5% dobitak na te\u017eini (93% RH)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753\u010cesto postavljana istra\u017eiva\u010dka pitanja<\/span><\/span><\/strong><\/h4>\n

                        P1: Koji je mehanizam djelovanja?<\/span><\/span><\/strong>
                        \n A: Primarni antagonizam NMDA receptora sa sekundarnom inhibicijom ponovnog preuzimanja dopamina.<\/span><\/span><\/p>\n

                        P2: Kako se snaga uspore\u0111uje s ketaminom?<\/span><\/span><\/strong>
                        \n A: ~0,6x ve\u0107a potentnost od ketamina, ali dulje vrijeme poluraspada (4-6 sati).<\/span><\/span><\/p>\n

                        P3: Postoje li neurotoksi\u010dni rizici?<\/span><\/span><\/strong>
                        \n A: Olneyjeve lezije nisu uo\u010dene pri <50 mg\/kg (studija na \u0161takorima).<\/span><\/span><\/p>\n

                        P4: Koji je optimalni na\u010din skladi\u0161tenja?<\/span><\/span><\/strong>
                        \n A: U originalnom pakiranju na temperaturi od 15-25\u00b0C, za\u0161ti\u0107eno od vlage.<\/span><\/span><\/p>\n

                        \ud83d\udcccOgrani\u010denja istra\u017eivanja<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Ograni\u010deni podaci o kroni\u010dnoj primjeni<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Nepoznati u\u010dinci na prijenos glutamata<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Varijabilna biotransformacija izme\u0111u vrsta<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dZaklju\u010dak za istra\u017eiva\u010de<\/span><\/span><\/strong><\/h4>\n

                          DMXE pelete od 40 mg nude standardiziranu formulaciju za precizna disocijativna istra\u017eivanja, s dosljednom isporukom doze i dobrom stabilno\u0161\u0107u. Oblik peleta olak\u0161ava kvantitativnu primjenu u studijama na \u017eivotinjama.<\/span><\/span><\/p>\n

                          Znanstvena izjava o odricanju od odgovornosti: Ovaj je proizvod namijenjen isklju\u010divo za in vitro istra\u017eivanja i odobrene predklini\u010dke studije. Nije za ljudsku upotrebu. Svi eksperimenti moraju biti u skladu s va\u017ee\u0107im eti\u010dkim smjernicama i lokalnim propisima. Imajte na umu poseban status psihoaktivnih istra\u017eiva\u010dkih tvari u va\u0161oj jurisdikciji.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          DMXE zna\u010dajke<\/span><\/span><\/span><\/span><\/h3>\n

                          Sinonim:<\/span><\/span><\/span><\/span><\/strong> Deoksimetoksilamin hidroklorid <\/span><\/span><\/span><\/span>
                          \nCAS broj:<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nFormula:<\/span><\/span><\/span><\/span><\/strong> 5-dehidro-1,3-kinodimetan <\/span><\/span><\/span><\/span>
                          \nMolarna masa:<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \n\u010cisto\u0107a:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28509,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28745,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product\/23358\/revisions\/28745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/media\/28509"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/hr\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}