Proskalin fumarat

Proscaline Fumarate – Scientific Product Documentation

🔬Kemijske specifikacije

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Osnovni parametri:

• Naziv po IUPAC-u : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Molekularna formula C₁₃H₂₁NO₃ · C₄H₄O₄

• Molekularna težina : 339.36 g/mol

• Čistoća : ≥98% (HPLC-UV at 254 nm)

• Oblik : White crystalline powder

• Melting point : 172-174°C (decomposes)

• Topljivost 15 mg/ml u vodi, 30 mg/ml u toplom etanolu

🧫Istraživačke primjene

1. Studije vezanja receptora :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Analiza metaboličkog puta :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Toksikološki podaci :

   • LD₅₀ (štakor, oralno): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Spektar nuspojava :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Kritične interakcije :

   • Opasno : MAO inhibitors, sympathomimetics

   • Riskantno : Serotonergic agents, vasopressors

📉Podaci o stabilnosti

• Rok trajanja : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Mass spectrum : [M+H]⁺ 240.2 m/z

• UV absorption λmax 282 nm (ε = 4200)

❓Research-oriented FAQ

P1: Koji je mehanizam djelovanja?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Ograničenja istraživanja

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.