{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23358"},"modified":"2025-10-30T10:10:50","modified_gmt":"2025-10-30T10:10:50","slug":"dmxe-40mg-pellets-deoxymethoxetamine","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/fr\/shop\/arylcyclohexylamine\/dmxe-40mg-pellets-deoxymethoxetamine\/","title":{"rendered":"Pastilles DMXE 40 mg (d\u00e9soxym\u00e9thox\u00e9tamine)"},"content":{"rendered":"

DMXE (d\u00e9oxym\u00e9thox\u00e9tamine) 40 mg, comprim\u00e9s \u2013 Documentation scientifique du produit<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cSp\u00e9cifications chimiques<\/span><\/span><\/strong><\/h4>\n

Le DMXE (2\u2032-oxo-PCE-d10) est un produit chimique de recherche appartenant \u00e0 la classe des arylcyclohexylamines, structurellement apparent\u00e9 au MXE (m\u00e9thox\u00e9tamine) et \u00e0 la k\u00e9tamine. Ces granul\u00e9s sont formul\u00e9s pour la recherche scientifique de pr\u00e9cision.<\/span><\/span><\/p>\n

Param\u00e8tres principaux\u00a0:<\/span><\/span><\/em><\/p>\n

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  • \n

    Nom de l'IUPAC<\/span><\/span><\/strong> : 2-(3,4-dim\u00e9thylph\u00e9nyl)-2-(\u00e9thylamino)cyclohexanone<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Formule mol\u00e9culaire<\/span><\/span><\/strong> : C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

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    Poids mol\u00e9culaire<\/span><\/span><\/strong> : 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Puret\u00e9<\/span><\/span><\/strong> : \u226598% (analyse GC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Forme<\/span><\/span><\/strong> : Plombs ronds de 4 mm de diam\u00e8tre<\/span><\/span><\/p>\n<\/li>\n

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    Couleur<\/span><\/span><\/strong> : Beige clair \u00e0 blanc<\/span><\/span><\/p>\n<\/li>\n

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    Solubilit\u00e9<\/span><\/span><\/strong> : 15 mg\/ml dans l'eau (\u00e0 25 \u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaApplications scientifiques<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Recherche neuropharmacologique<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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      • \n

        \u00c9tudes sur l'antagonisme des r\u00e9cepteurs NMDA<\/span><\/span><\/p>\n<\/li>\n

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        Tests d'interaction avec le r\u00e9cepteur Sigma-1<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Neurosciences comportementales<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Effets sur le comportement d'apprentissage chez les animaux de laboratoire<\/span><\/span><\/p>\n<\/li>\n

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          effets dissociatifs dose-d\u00e9pendants<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Psychopharmacologie<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            \u00c9tudes comparatives avec des dissociatifs apparent\u00e9s<\/span><\/span><\/p>\n<\/li>\n

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            Recherche sur les effets neuroplastiques<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fProtocoles de recherche recommand\u00e9s<\/span><\/span><\/strong><\/h4>\n

            Directives exp\u00e9rimentales\u00a0:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/span><\/span><\/th>\nDosage<\/span><\/span><\/th>\nFr\u00e9quence<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10-50 \u03bcM<\/span><\/span><\/td>\nexposition unique<\/span><\/span><\/td>\n<\/tr>\n
            Petits rongeurs<\/span><\/span><\/td>\n5-20 mg\/kg<\/span><\/span><\/td>\n1 fois par jour (maximum 3 jours)<\/span><\/span><\/td>\n<\/tr>\n
            Primates<\/span><\/span><\/td>\n1 \u00e0 5 mg\/kg<\/span><\/span><\/td>\ndose unique<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Remarque\u00a0: Pharmacocin\u00e9tique non lin\u00e9aire au-del\u00e0 de 25\u00a0mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fProfil de s\u00e9curit\u00e9 et gestion des risques<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Donn\u00e9es toxicologiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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              • \n

                DL\u2085\u2080 (rat, voie orale) : 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL\u00a0: 5\u00a0mg\/kg\/jour (\u00e9tude de 7\u00a0jours)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Spectre des effets secondaires<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                • \n

                  <10 mg : Effets comportementaux subtils<\/span><\/span><\/p>\n<\/li>\n

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                  10-30 mg : Incoordination motrice<\/span><\/span><\/p>\n<\/li>\n

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                  \n

                  30 mg : Risque de d\u00e9pression respiratoire<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Interactions critiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                  • \n

                    Dangereux<\/span><\/span><\/strong> : Opio\u00efdes, GABAergiques<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Risqu\u00e9<\/span><\/span><\/strong> Stimulants, inhibiteurs de la MAO<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaContr\u00f4le de la qualit\u00e9 et donn\u00e9es analytiques<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      puret\u00e9 HPLC<\/span><\/span><\/strong> : 98,5% (colonne C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Uniformit\u00e9<\/span><\/span><\/strong> : \u00b15% \u00e9cart de poids (n=20 granul\u00e9s)<\/span><\/span><\/p>\n<\/li>\n

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                      Temps de d\u00e9sint\u00e9gration<\/span><\/span><\/strong> : <15 minutes (dans le suc gastrique simultan\u00e9)<\/span><\/span><\/p>\n<\/li>\n

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                      Donn\u00e9es de stabilit\u00e9<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                      • \n

                        Dur\u00e9e de conservation : 24 mois \u00e0 une temp\u00e9rature de 15 \u00e0 25 \u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Sensibilit\u00e9 \u00e0 l'humidit\u00e9 : gain de poids < 0,5% (93% HR)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Questions fr\u00e9quemment pos\u00e9es sur la recherche<\/span><\/span><\/strong><\/h4>\n

                        Q1 : Quel est le m\u00e9canisme d'action ?<\/span><\/span><\/strong>
                        \n A : Antagonisme primaire des r\u00e9cepteurs NMDA avec inhibition secondaire de la recapture de la dopamine.<\/span><\/span><\/p>\n

                        Q2 : Quelle est sa puissance par rapport \u00e0 la k\u00e9tamine ?<\/span><\/span><\/strong>
                        \n A : ~0,6 fois la puissance de la k\u00e9tamine mais une demi-vie plus longue (4 \u00e0 6 heures).<\/span><\/span><\/p>\n

                        Q3 : Existe-t-il des risques neurotoxiques ?<\/span><\/span><\/strong>
                        \n A : Les l\u00e9sions d'Olney n'ont pas \u00e9t\u00e9 observ\u00e9es \u00e0 <50 mg\/kg (\u00e9tude sur les rats).<\/span><\/span><\/p>\n

                        Q4 : Quelle est la m\u00e9thode de stockage optimale ?<\/span><\/span><\/strong>
                        \n A: Dans son emballage d'origine, \u00e0 une temp\u00e9rature de 15 \u00e0 25 \u00b0C, \u00e0 l'abri de l'humidit\u00e9.<\/span><\/span><\/p>\n

                        \ud83d\udcccLimites de la recherche<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Donn\u00e9es limit\u00e9es sur l'administration chronique<\/span><\/span><\/p>\n<\/li>\n

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                          Effets inconnus sur la transmission du glutamate<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Biotransformation variable selon les esp\u00e8ces<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclusion \u00e0 l'intention des chercheurs<\/span><\/span><\/strong><\/h4>\n

                          Les granul\u00e9s de DMXE 40 mg offrent une formulation standardis\u00e9e pour des recherches dissociatives pr\u00e9cises, avec une administration de dose constante et une bonne stabilit\u00e9. Leur forme facilite l'administration quantitative lors d'\u00e9tudes animales.<\/span><\/span><\/p>\n

                          Avertissement scientifique\u00a0: Ce produit est exclusivement destin\u00e9 \u00e0 la recherche in vitro et aux \u00e9tudes pr\u00e9cliniques autoris\u00e9es. Il ne doit pas \u00eatre utilis\u00e9 chez l\u2019humain. Toutes les exp\u00e9riences doivent respecter les directives \u00e9thiques et les r\u00e9glementations locales en vigueur. Veuillez vous renseigner sur le statut particulier des substances psychoactives utilis\u00e9es \u00e0 des fins de recherche dans votre pays ou r\u00e9gion.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Fonctionnalit\u00e9s DMXE<\/span><\/span><\/span><\/span><\/h3>\n

                          Synonyme:<\/span><\/span><\/span><\/span><\/strong> Chlorhydrate de d\u00e9soxym\u00e9thox\u00e9tamine <\/span><\/span><\/span><\/span>
                          \nNum\u00e9ro CAS :<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nFormule:<\/span><\/span><\/span><\/span><\/strong> 5-d\u00e9hydro-1,3-quinodim\u00e9thane <\/span><\/span><\/span><\/span>
                          \nMasse molaire :<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \nPuret\u00e9:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28509,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28745,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product\/23358\/revisions\/28745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/media\/28509"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fr\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}