{"id":23399,"date":"2025-04-13T17:39:42","date_gmt":"2025-04-13T17:39:42","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23399"},"modified":"2025-10-30T10:03:36","modified_gmt":"2025-10-30T10:03:36","slug":"proskaliinifumaraatti","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/fi\/kauppa\/melkein-kielletty\/proskaliinifumaraatti\/","title":{"rendered":"Proskaliinifumaraatti"},"content":{"rendered":"

Proscaline Fumarate \u2013 Scientific Product Documentation<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cChemical Specifications<\/span><\/span><\/strong><\/h4>\n

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.<\/span><\/span><\/p>\n

Core parameters:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    IUPAC name<\/span><\/span><\/strong> : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molecular formula<\/span><\/span><\/strong> : C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molecular weight<\/span><\/span><\/strong> : 339.36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Purity<\/span><\/span><\/strong> : \u226598% (HPLC-UV at 254 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Form<\/span><\/span><\/strong> : White crystalline powder<\/span><\/span><\/p>\n<\/li>\n

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    Melting point<\/span><\/span><\/strong> : 172-174\u00b0C (decomposes)<\/span><\/span><\/p>\n<\/li>\n

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    Solubility<\/span><\/span><\/strong> : 15 mg\/ml in water, 30 mg\/ml in warm ethanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddebResearch applications<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Receptor binding studies<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        5-HT\u2082A agonism (EC\u2085\u2080 = 280 nM)<\/span><\/span><\/p>\n<\/li>\n

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        Dopaminergic modulation research<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Neurophysiological examination<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          EEG pattern analysis in experimental animals<\/span><\/span><\/p>\n<\/li>\n

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          Comparative studies with classical psychedelics<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metabolic pathway analysis<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            O-demethylation kinetics<\/span><\/span><\/p>\n<\/li>\n

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            CYP2D6 interaction profile<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0fExperimental Protocols<\/span><\/span><\/strong><\/h4>\n

            Standard research conditions:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/span><\/span><\/th>\nConcentration<\/span><\/span><\/th>\nExposure time<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10-100 \u03bcM<\/span><\/span><\/td>\n15-60 minutes<\/span><\/span><\/td>\n<\/tr>\n
            In vivo<\/span><\/span><\/td>\n1-5 mg\/kg<\/span><\/span><\/td>\nAcute\/chronic<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Note: Show non-linear pharmacokinetics above 8 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fSafety profile<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toxicological data<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (rat, oral): 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL: 0.75 mg\/kg\/day (28-day study)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Side effect spectrum<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                • \n

                  Dose-dependent effects:<\/span><\/span><\/p>\n

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                  • \n

                    <3 mg\/kg: Subtle sensory changes<\/span><\/span><\/p>\n<\/li>\n

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                    3-6 mg\/kg: Vegetative symptoms<\/span><\/span><\/p>\n<\/li>\n

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                    \n

                    6 mg\/kg: Potential hemodynamic instability<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

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                    Critical Interactions<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    • \n

                      Dangerous<\/span><\/span><\/strong> : MAO inhibitors, sympathomimetics<\/span><\/span><\/p>\n<\/li>\n

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                      Risky<\/span><\/span><\/strong> : Serotonergic agents, vasopressors<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9Stability data<\/span><\/span><\/strong><\/h4>\n
                        \n
                      • \n

                        Shelf life<\/span><\/span><\/strong> : 24 months at -20\u00b0C (under argon)<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Degradation products<\/span><\/span><\/strong> : <2% after 12 months RT<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Compatible buffers<\/span><\/span><\/strong> : PBS (pH 7.4), hydrochloric acid (0.1N)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0dAnalytical Features<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          HPLC retention time<\/span><\/span><\/strong> : 6.8 min (C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Mass spectrum<\/span><\/span><\/strong> : [M+H]\u207a 240.2 m\/z<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          UV absorption<\/span><\/span><\/strong> : \u03bbmax 282 nm (\u03b5 = 4200)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \u2753Research-oriented FAQ<\/span><\/span><\/strong><\/h4>\n

                          Q1: What is the mechanism of action?<\/span><\/span><\/strong>
                          \n A: Primary 5-HT\u2082A receptor partial agonist with secondary DAT interaction.<\/span><\/span><\/p>\n

                          Q2: How does the potency compare to mescaline?<\/span><\/span><\/strong>
                          \n A: ~3x higher 5-HT\u2082A affinity but lower blood-brain barrier penetration.<\/span><\/span><\/p>\n

                          Q3: Are there genotoxic risks?<\/span><\/span><\/strong>
                          \n A: Ames test negative up to 1 mM, but limited chromosome test data.<\/span><\/span><\/p>\n

                          Q4: What is the optimal formulation?<\/span><\/span><\/strong>
                          \n A: Sterile saline (0.9% NaCl) for in vivo studies.<\/span><\/span><\/p>\n

                          \ud83d\udcccResearch limitations<\/span><\/span><\/strong><\/h4>\n
                            \n
                          • \n

                            Limited data on chronic exposure<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Unknown neuroplastic effects<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Variable interspecies metabolism<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.<\/span><\/span><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

                            Proskaliinifumaraatti<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonyymi:<\/span><\/span><\/span><\/span><\/strong> 3,5-dimetoksi-4-propoksifenetyyliamiinifumaraatti <\/span><\/span><\/span><\/span>
                            \nCAS-numero:<\/span><\/span><\/span><\/span><\/strong> 39201-78-0 <\/span><\/span><\/span><\/span>
                            \nKaava:<\/span><\/span><\/span><\/span><\/strong> 2-{3,5-dimetoksi-4-propyylioksifenyyli}etaani-1-amiinifumaraatti <\/span><\/span><\/span><\/span>
                            \nMoolimassa:<\/span><\/span><\/span><\/span><\/strong> 355,4 g\/mol <\/span><\/span><\/span><\/span>
                            \nPuhtaus:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28591,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,536],"product_tag":[326,1211],"class_list":{"0":"post-23399","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","10":"product_tag-proscaline-fumarate","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product\/23399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/comments?post=23399"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product\/23399\/revisions"}],"predecessor-version":[{"id":28739,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product\/23399\/revisions\/28739"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/media\/28591"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/media?parent=23399"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product_brand?post=23399"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product_cat?post=23399"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/fi\/wp-json\/wp\/v2\/product_tag?post=23399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}