{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23378"},"modified":"2025-06-30T11:38:45","modified_gmt":"2025-06-30T11:38:45","slug":"eskaliinvesinikkloriid","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/et\/pood\/peaaegu-keelatud\/eskaliinvesinikkloriid\/","title":{"rendered":"Eskaliinvesinikkloriid"},"content":{"rendered":"

Eskaliinvesinikkloriid \u2013 teaduslik tootedokumentatsioon<\/strong><\/h3>\n

\ud83d\udd2c Keemilised spetsifikatsioonid<\/strong><\/h4>\n

Eskaliin (4-etoks\u00fc-3,5-dimetoks\u00fcfenet\u00fc\u00fclamiin) vesinikkloriid on pools\u00fcnteetiline fenet\u00fc\u00fclamiini derivaat, mis on struktuurilt seotud meskaliiniga. Seda uurimis\u00fchendit uuritakse selle huvitava farmakoloogilise profiili t\u00f5ttu.<\/p>\n

P\u00f5hiparameetrid:<\/em><\/p>\n

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    IUPAC-nimetus<\/strong>: 2-(4-etoks\u00fc-3,5-dimetoks\u00fcfen\u00fc\u00fcl)etaan-1-amiinvesinikkloriid<\/p>\n<\/li>\n

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    Molekulaarne valem<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

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    Molekulaarmass<\/strong>261,75 g\/mol<\/p>\n<\/li>\n

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    Puhtus<\/strong>\u226598% (HPLC-UV lainepikkusel 280 nm)<\/p>\n<\/li>\n

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    Vorm<\/strong>Valge kristalliline pulber<\/p>\n<\/li>\n

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    Sulamistemperatuur<\/strong>: 243\u2013245 \u00b0C (laguneb)<\/p>\n<\/li>\n

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    Lahustuvus<\/strong>50 mg\/ml vees, 30 mg\/ml metanoolis<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Teaduslikud rakendused<\/strong><\/h4>\n
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    1. \n

      Neurofarmakoloogilised uuringud<\/strong>:<\/p>\n

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        5-HT\u2082A retseptori sidumise uuringud (Ki = 120 nM)<\/p>\n<\/li>\n

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        Meskaliini ja teiste fenet\u00fc\u00fclamiinide v\u00f5rdlevad uuringud<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        K\u00e4itumisuuringud<\/strong>:<\/p>\n

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          M\u00f5ju loomade k\u00e4itumisele kontrollitud keskkondades<\/p>\n<\/li>\n

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          Annuse-vastuse seosed imetajate mudelites<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Ainevahetusuuringud<\/strong>:<\/p>\n

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            O-dealk\u00fc\u00fclimise kineetika uuring<\/p>\n<\/li>\n

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            CYP2D6 interaktsiooniprofiil<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Soovitatavad annused uuringuteks<\/strong><\/h4>\n

            Katsejuhised:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mudel<\/th>\nAnnustamine<\/th>\nAdministratsiooni tee<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\nRakukultuuri s\u00f6\u00f6de<\/td>\n<\/tr>\n
            V\u00e4ikesed loomad<\/td>\n1\u20135 mg\/kg<\/td>\nIntraperitoneaalne<\/td>\n<\/tr>\n
            Primaadid<\/td>\n0,2\u20131 mg\/kg<\/td>\nSuuline<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *M\u00e4rkus: Annusest s\u00f5ltuvad toimed \u00fcle 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Ohutusaspektid ja riskid<\/strong><\/h4>\n
              \n
            1. \n

              Toksikoloogilised andmed<\/strong>:<\/p>\n

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                LD\u2085\u2080 (hiir, intravenoosselt): 185 mg\/kg<\/p>\n<\/li>\n

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                NOAEL: 0,75 mg\/kg\/p\u00e4evas (28-p\u00e4evane uuring)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                K\u00f5rvaltoimete profiil<\/strong>:<\/p>\n

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                • \n

                  <2 mg\/kg: Minimaalsed f\u00fcsioloogilised m\u00f5jud<\/p>\n<\/li>\n

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                  2\u20136 mg\/kg: Sensoorne modulatsioon<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: V\u00f5imalikud hemod\u00fcnaamilised toimed<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Kriitilised interaktsioonid<\/strong>:<\/p>\n

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                    Ohtlik<\/strong>MAO inhibiitorid, serotonergilised ained<\/p>\n<\/li>\n

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                    Riskantne<\/strong>Vasokonstriktorid, antips\u00fchhootikumid<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kvaliteedikontroll ja anal\u00fc\u00fctilised andmed<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC puhtus<\/strong>98,2% (C18 kolonn, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

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                      J\u00e4\u00e4nud lahustid<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

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                      Stabiilsusandmed<\/strong>:<\/p>\n

                        \n
                      • \n

                        S\u00e4ilivusaeg: 24 kuud temperatuuril -20\u00b0C<\/p>\n<\/li>\n

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                        Toatemperatuur: 6 kuud (argooni atmosf\u00e4\u00e4ris)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Korduma kippuvad uurimisk\u00fcsimused<\/strong><\/h4>\n

                        K1: Milline on toimemehhanism?<\/strong>
                        \nA: Peamine toime 5-HT\u2082A retseptori agonistina, millel on sekundaarne toime dopamiinergilistele s\u00fcsteemidele.<\/p>\n

                        K2: Kuidas on selle tugevus v\u00f5rreldav meskaliiniga?<\/strong>
                        \nA: Ligikaudu 1,5 korda suurem retseptori afiinsus, kuid pikem toimeaeg (8\u201310 tundi).<\/p>\n

                        K3: Millised on optimaalsed s\u00e4ilitustingimused?<\/strong>
                        \nA: Merevaikkollastes viaalides inertgaasi all temperatuuril -20 \u00b0C.<\/p>\n

                        K4: Kas esineb genotoksilisi riske?<\/strong>
                        \nA: Ames'i test on negatiivne <1 mM juures, kuid kromosoomitesti andmed on piiratud.<\/p>\n

                        \ud83d\udccc Uuringu piirangud<\/strong><\/h4>\n
                          \n
                        • \n

                          Piiratud andmed kroonilise kokkupuute kohta<\/p>\n<\/li>\n

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                          Tundmatu m\u00f5ju neuroplastilisusele<\/p>\n<\/li>\n

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                          Muutuv liikidevaheline ainevahetus<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Teadlaste j\u00e4reldus<\/strong><\/h4>\n

                          Eskaliinvesinikkloriid pakub v\u00e4\u00e4rtuslikke v\u00f5imalusi serotoniini v\u00f5rdlevaks uurimiseks, pakkudes ainulaadset stabiilsuse ja pikaealisuse kombinatsiooni. Vesinikkloriidvorm tagab suurep\u00e4rase lahustuvuse laborirakendustes.<\/p>\n

                          Oluline vastutusest loobumise klausel: See toode on ette n\u00e4htud \u00fcksnes teaduslikuks uurimist\u00f6\u00f6ks akrediteeritud laborites. Mitte inimtoiduks ega diagnostiliseks kasutamiseks. K\u00f5ik katsed tuleb l\u00e4bi viia vastavalt kohalikele eeskirjadele ja eetilistele juhistele.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Eskaliini vesinikkloriidi omadused<\/span><\/h3>\n

                          S\u00fcnon\u00fc\u00fcm:<\/strong> 3,5-dimetoks\u00fc-4-etoks\u00fcfenet\u00fc\u00fclamiinvesinikkloriid
                          \nCAS-number:<\/strong> 39201-82-6
                          \nValem:<\/strong> 2-{3,5-dimetoks\u00fc-4-et\u00fc\u00fcloks\u00fcfen\u00fc\u00fcl}etaan-1-amiinvesinikkloriid
                          \nMolaarmass:<\/strong> 261,8 g\/mol
                          \nPuhtus:<\/strong> >97%<\/p>","protected":false},"featured_media":20228,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/media\/20228"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"t\u00f6\u00f6leht","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}