{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23358"},"modified":"2025-10-30T10:10:50","modified_gmt":"2025-10-30T10:10:50","slug":"dmxe-40mg-pellets-deoxymethoxetamine","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/et\/shop\/arylcyclohexylamine\/dmxe-40mg-pellets-deoxymethoxetamine\/","title":{"rendered":"DMXE 40 mg graanulid (deoks\u00fcmetoks\u00fcetamiin)"},"content":{"rendered":"

DMXE (deoks\u00fcmetoks\u00fcetamiin) 40 mg graanulid \u2013 teaduslik tootedokumentatsioon<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cKeemilised spetsifikatsioonid<\/span><\/span><\/strong><\/h4>\n

DMXE (2\u2032-okso-PCE-d10) on ar\u00fc\u00fclts\u00fckloheks\u00fc\u00fclamiinide klassi kuuluv uurimiskemikaal, mis on struktuurilt seotud MXE (metoksetamiini) ja ketamiiniga. Need graanulid on loodud t\u00e4ppisteaduslikuks uurimist\u00f6\u00f6ks.<\/span><\/span><\/p>\n

P\u00f5hiparameetrid:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    IUPAC-nimetus<\/span><\/span><\/strong> : 2-(3,4-dimet\u00fc\u00fclfen\u00fc\u00fcl)-2-(et\u00fc\u00fclamino)ts\u00fckloheksanoon<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekulaarne valem<\/span><\/span><\/strong> C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekulaarmass<\/span><\/span><\/strong> 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Puhtus<\/span><\/span><\/strong> : \u226598% (GC-MS anal\u00fc\u00fcs)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Kuju<\/span><\/span><\/strong> \u00dcmmargused, 4 mm l\u00e4bim\u00f5\u00f5duga graanulid<\/span><\/span><\/p>\n<\/li>\n

  • \n

    V\u00e4rv<\/span><\/span><\/strong> Helebee\u017e kuni valge<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Lahustuvus<\/span><\/span><\/strong> 15 mg\/ml vees (temperatuuril 25 \u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaTeaduslikud rakendused<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakoloogilised uuringud<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

        \n
      • \n

        NMDA retseptori antagonismi uuringud<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Sigma-1 retseptori interaktsiooni testid<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        K\u00e4itumuslik neuroteadus<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

          \n
        • \n

          M\u00f5ju laboriloomade \u00f5ppimisk\u00e4itumisele<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Annusest s\u00f5ltuvad dissotsiatiivsed efektid<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Ps\u00fchhofarmakoloogia<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

            \n
          • \n

            V\u00f5rdlevad uuringud seotud dissotsiatiividega<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Neuroplastiliste efektide uuringud<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fSoovitatavad uurimisprotokollid<\/span><\/span><\/strong><\/h4>\n

            Katsejuhised:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mudel<\/span><\/span><\/th>\nAnnustamine<\/span><\/span><\/th>\nSagedus<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10\u201350 \u03bcM<\/span><\/span><\/td>\n\u00dchekordne s\u00e4ritus<\/span><\/span><\/td>\n<\/tr>\n
            V\u00e4ikesed n\u00e4rilised<\/span><\/span><\/td>\n5\u201320 mg\/kg<\/span><\/span><\/td>\n1 kord p\u00e4evas (maksimaalselt 3 p\u00e4eva)<\/span><\/span><\/td>\n<\/tr>\n
            Primaadid<\/span><\/span><\/td>\n1\u20135 mg\/kg<\/span><\/span><\/td>\n\u00dchekordne annus<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *M\u00e4rkus: Mittelineaarne farmakokineetika \u00fcle 25 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fOhutusprofiil ja riskijuhtimine<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toksikoloogilised andmed<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (rott, suukaudne): 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

              • \n

                NOAEL: 5 mg\/kg\/p\u00e4evas (7-p\u00e4evane uuring)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                K\u00f5rvaltoimete spekter<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                  \n
                • \n

                  <10 mg: peened k\u00e4itumuslikud m\u00f5jud<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  10\u201330 mg: motoorne koordinatsioonih\u00e4ire<\/span><\/span><\/p>\n<\/li>\n

                • \n
                  \n

                  30 mg: V\u00f5imalik hingamisdepressioon<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kriitilised interaktsioonid<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                    \n
                  • \n

                    Ohtlik<\/span><\/span><\/strong> Opioidid, GABA-ergilised ained<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Riskantne<\/span><\/span><\/strong> Stimulandid, MAO inhibiitorid<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaKvaliteedikontroll ja anal\u00fc\u00fctilised andmed<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC puhtus<\/span><\/span><\/strong> 98,5% (C18 kolonn, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u00dchtlus<\/span><\/span><\/strong> : \u00b15% kaaluh\u00e4lve (n = 20 graanulit)<\/span><\/span><\/p>\n<\/li>\n

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                      Lagunemisaeg<\/span><\/span><\/strong> <15 minutit (samaaegselt maomahlaga)<\/span><\/span><\/p>\n<\/li>\n

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                      Stabiilsusandmed<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        S\u00e4ilivusaeg: 24 kuud temperatuuril 15\u201325 \u00b0C<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Niiskustundlikkus: <0,5% kaalut\u00f5us (93% suhteline niiskus)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Korduma kippuvad uurimisk\u00fcsimused<\/span><\/span><\/strong><\/h4>\n

                        K1: Milline on toimemehhanism?<\/span><\/span><\/strong>
                        \n A: Primaarne NMDA retseptori antagonism koos sekundaarse dopamiini tagasihaarde inhibeerimisega.<\/span><\/span><\/p>\n

                        K2: Kuidas on selle tugevus v\u00f5rreldes ketamiiniga?<\/span><\/span><\/strong>
                        \n A: ~0,6 korda tugevam kui ketamiinil, aga pikem poolv\u00e4\u00e4rtusaeg (4\u20136 tundi).<\/span><\/span><\/p>\n

                        K3: Kas esineb neurotoksilisi riske?<\/span><\/span><\/strong>
                        \n A: Olney kahjustusi ei t\u00e4heldatud annuse <50 mg\/kg korral (rottide uuring).<\/span><\/span><\/p>\n

                        K4: Milline on optimaalne salvestusmeetod?<\/span><\/span><\/strong>
                        \n A: Originaalpakendis temperatuuril 15\u201325 \u00b0C, niiskuse eest kaitstult.<\/span><\/span><\/p>\n

                        \ud83d\udcccUuringu piirangud<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Piiratud andmed kroonilise manustamise kohta<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Tundmatu m\u00f5ju glutamaadi \u00fclekandele<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Liikidevaheline varieeruv biotransformatsioon<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dKokkuv\u00f5te teadlastele<\/span><\/span><\/strong><\/h4>\n

                          DMXE 40 mg graanulid pakuvad standardiseeritud koostist t\u00e4pseks dissotsiatiivseks uurimist\u00f6\u00f6ks, tagades \u00fchtlase annuse manustamise ja hea stabiilsuse. Graanulite vorm h\u00f5lbustab kvantitatiivset manustamist loomkatsetes.<\/span><\/span><\/p>\n

                          Teaduslik vastutusest loobumine: See toode on ette n\u00e4htud \u00fcksnes in vitro uuringuteks ja volitatud prekliinilisteks uuringuteks. Mitte inimestele. K\u00f5ik katsed peavad vastama kehtivatele eetikanormidele ja kohalikele eeskirjadele. Palun arvestage ps\u00fchhoaktiivsete uurimisainete eristaatusega teie jurisdiktsioonis.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          DMXE funktsioonid<\/span><\/span><\/span><\/span><\/h3>\n

                          S\u00fcnon\u00fc\u00fcm:<\/span><\/span><\/span><\/span><\/strong> Deoks\u00fcmetoks\u00fcetamiinvesinikkloriid <\/span><\/span><\/span><\/span>
                          \nCAS-number:<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nValem:<\/span><\/span><\/span><\/span><\/strong> 5-deh\u00fcdro-1,3-kinodimetaan <\/span><\/span><\/span><\/span>
                          \nMolaarmass:<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \nPuhtus:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28509,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28745,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product\/23358\/revisions\/28745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/media\/28509"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/et\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"t\u00f6\u00f6leht","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}