Proskaliinfumaraat

Proscaline Fumarate – Scientific Product Documentation

🔬Keemilised spetsifikatsioonid

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Põhiparameetrid:

• IUPAC-nimetus : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Molekulaarne valem C₁₃H₂₁NO₃ · C₄H₄O₄

• Molekulaarmass : 339.36 g/mol

• Puhtus : ≥98% (HPLC-UV at 254 nm)

• Vorm : White crystalline powder

• Sulamistemperatuur : 172-174°C (decomposes)

• Lahustuvus 15 mg/ml vees, 30 mg/ml soojas etanoolis

🧫Teadustöö rakendused

1. Retseptori sidumise uuringud :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Ainevahetusradade analüüs :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Toksikoloogilised andmed :

   • LD₅₀ (rott, suukaudne): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Kõrvaltoimete spekter :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Kriitilised interaktsioonid :

   • Ohtlik : MAO inhibitors, sympathomimetics

   • Riskantne : Serotonergic agents, vasopressors

📉Stabiilsusandmed

• Säilivusaeg : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Massispekter : [M+H]⁺ 240.2 m/z

• UV absorption λmax 282 nm (ε = 4200)

❓Research-oriented FAQ

K1: Milline on toimemehhanism?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

K2: Kuidas on selle tugevus võrreldav meskaliiniga?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Uuringu piirangud

• Piiratud andmed kroonilise kokkupuute kohta

• Tundmatud neuroplastilised mõjud

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.