O-DSMT (O-Desmethyltramadol) – Scientific Information and Analytical Overview

Meta description:
O-DSMT (O-Desmethyltramadol) is a research drug and a pharmacologically active metabolite of tramadol. Learn more about the chemical structure, mechanism of action, scientific relevance, and safety aspects of O-DSMT.

Introduction

O-Desmethyltramadol (O-DSMT) is a synthetic compound which belongs to the group of opioid analgesics. It is the active metabolite of tramadol, an analgesic used worldwide for the treatment of moderate to severe pain.

O-DSMT is formed in the body when tramadol is metabolized by the liver via the enzyme CYP2D6. This metabolite is responsible for a large part of the analgesic effect of tramadol. In a research context, O-DSMT is being studied to pharmacological action, receptor activity and safety to better understand opioid compounds.

O-DSMT is sometimes mentioned in scientific literature on new psychoactive substances (NPS) and forensic toxicology, but it is not approved for human use or consumption.

Key Features

Scientific Relevance and Research Value

• Pharmacological research
  O-DSMT is used to mechanisms of pain relief Better understand and compare it with other opioid agonists. This helps researchers gain insight into receptor selectivity, metabolic pathways, and structural variations.

• Toxicological analysis
  In forensic and clinical toxicology laboratories, O-DSMT is used as reference or calibration substance to analyze biological samples (such as blood or urine) for the presence of tramadol metabolites.

• Analytical characterization
  The material is examined using techniques such as LC-MS/MS, GC-MS and NMR to enable identification and quantification in research samples.

• Regulatory and safety studies
  O-DSMT helps develop detection protocols for new psychoactive substances (NPS) and in the assessment of risks to public health and potential for abuse.

Laboratory Use (For Research Only)

⚠️ Important:
O-DSMT is intended for scientific research only in authorized laboratories.
It is not intended for human consumption, self-medication or recreational use.

1. Storage and Stability

   • Store in a closed container, dry and cool (2–8 °C).

   • Protect from light, moisture and air.

   • Use only within institutions with valid research permits.

2. Analytical Application

   • Used as a standard in LC-MS and GC-MS analysis to identify tramadol metabolites.

   • Suitable for methodological validation in toxicological or pharmaceutical studies.

3. Safety in the Laboratory

   • Always wear gloves, safety glasses and a lab coat.

   • Avoid contact with skin, eyes or mucous membranes.

   • Dispose of waste in accordance with chemical safety regulations and national regulations.

Legal Information

O-DSMT is covered by the Opium Act or similar arrangements for opioid substances.
Researchers and laboratories must prior consent obtain for the storage, transport or use of O-DSMT in a research context.

The fabric may not be sold or used outside of accredited research institutions. Unauthorized possession or use may result in criminal prosecution.

Frequently Asked Questions (FAQ)

1️⃣ What exactly is O-DSMT?
O-DSMT is the active metabolite of tramadol, formed in the body after tramadol intake. In research settings, it is used to study the pharmacology of opioids.

2️⃣ Is O-DSMT legal?
The legal status varies by country. In most European countries, O-DSMT falls under opioid legislation, which means it can only be used for scientific or forensic purposes.

3️⃣ Can O-DSMT be used for personal use or microdosing?
No. O-DSMT is not approved for human consumption and may only be used in a controlled laboratory environment. Unauthorized use is dangerous and illegal.

References and Further Information

• European Monitoring Center for Drugs and Drug Addiction (EMCDDA): Report on New Psychoactive Substances (NPS) – Opioids and tramadol derivatives.

• National Institute on Drug Abuse (NIDA): Synthetic Opioids and Emerging Analogue Compounds.

• Forensic Toxicology Journals: Analytical Identification and Pharmacology of O-Desmethyltramadol.

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