{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalhub.com\/?post_type=product&p=23378"},"modified":"2025-06-30T11:38:45","modified_gmt":"2025-06-30T11:38:45","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/researchchemicalhub.com\/da\/shop\/bijna-verboden\/escaline-hydrochloride\/","title":{"rendered":"Escalinehydrochlorid"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Videnskabelig produktdokumentation<\/strong><\/h3>\n

\ud83d\udd2c Kemiske specifikationer<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyphenethylamin) hydrochlorid er et semisyntetisk phenethylaminderivat, der er strukturelt besl\u00e6gtet med meskalin. Denne forskningsforbindelse unders\u00f8ges for sin interessante farmakologiske profil.<\/p>\n

Kerneparametre:<\/em><\/p>\n

    \n
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    IUPAC-navn<\/strong>2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-aminhydrochlorid<\/p>\n<\/li>\n

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    Molekylformel<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

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    Molekylv\u00e6gt<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

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    Renhed<\/strong>: \u226598% (HPLC-UV ved 280 nm)<\/p>\n<\/li>\n

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    Form<\/strong>Hvidt krystallinsk pulver<\/p>\n<\/li>\n

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    Smeltepunkt<\/strong>: 243-245\u00b0C (nedbrydes)<\/p>\n<\/li>\n

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    Opl\u00f8selighed<\/strong>50 mg\/ml i vand, 30 mg\/ml i methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Videnskabelige anvendelser<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologisk forskning<\/strong>:<\/p>\n

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        5-HT\u2082A-receptorbindingsstudier (Ki = 120 nM)<\/p>\n<\/li>\n

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        Sammenlignende studier af meskalin og andre phenethylaminer<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Adf\u00e6rdsforskning<\/strong>:<\/p>\n

          \n
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          Effekter p\u00e5 dyreadf\u00e6rd i kontrollerede milj\u00f8er<\/p>\n<\/li>\n

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          Dosis-responsforhold i pattedyrmodeller<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metaboliske studier<\/strong>:<\/p>\n

            \n
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            O-dealkyleringskinetikunders\u00f8gelse<\/p>\n<\/li>\n

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            CYP2D6 interaktionsprofil<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Anbefalede doser til forskning<\/strong><\/h4>\n

            Eksperimentelle retningslinjer:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nDosering<\/th>\nAdministrationsvej<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nCellekulturmedium<\/td>\n<\/tr>\n
            Sm\u00e5 dyr<\/td>\n1-5 mg\/kg<\/td>\nIntraperitoneal<\/td>\n<\/tr>\n
            Primater<\/td>\n0,2-1 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Bem\u00e6rk: Dosisafh\u00e6ngige effekter over 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Sikkerhedsaspekter og risici<\/strong><\/h4>\n
              \n
            1. \n

              Toksikologiske data<\/strong>:<\/p>\n

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                LD\u2085\u2080 (mus, iv): 185 mg\/kg<\/p>\n<\/li>\n

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                NOAEL: 0,75 mg\/kg\/dag (28-dages studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Bivirkningsprofil<\/strong>:<\/p>\n

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                  <2 mg\/kg: Minimale fysiologiske effekter<\/p>\n<\/li>\n

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                  2-6 mg\/kg: Sensorisk modulering<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potentielle h\u00e6modynamiske effekter<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritiske interaktioner<\/strong>:<\/p>\n

                    \n
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                    Farlig<\/strong>MAO-h\u00e6mmere, serotonerge midler<\/p>\n<\/li>\n

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                    Risikabel<\/strong>Vasokonstriktorer, antipsykotika<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kvalitetskontrol og analytiske data<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC-renhed<\/strong>98,2% (C18-s\u00f8jle, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Resterende opl\u00f8sningsmidler<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Stabilitetsdata<\/strong>:<\/p>\n

                        \n
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                        Holdbarhed: 24 m\u00e5neder ved -20\u00b0C<\/p>\n<\/li>\n

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                        Stuetemperatur: 6 m\u00e5neder (under argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Ofte stillede forskningssp\u00f8rgsm\u00e5l<\/strong><\/h4>\n

                        Q1: Hvad er virkningsmekanismen?<\/strong>
                        \nA: Prim\u00e6r virkning som en 5-HT\u2082A-receptoragonist med sekund\u00e6re effekter p\u00e5 dopaminerge systemer.<\/p>\n

                        Q2: Hvordan er styrken sammenlignet med meskalin?<\/strong>
                        \nA: Cirka 1,5 gange h\u00f8jere receptoraffinitet, men l\u00e6ngere virkningsvarighed (8-10 timer).<\/p>\n

                        Q3: Hvad er optimale opbevaringsforhold?<\/strong>
                        \nA: I ravfarvede h\u00e6tteglas under inert gas ved -20 \u00b0C.<\/p>\n

                        Q4: Er der genotoksiske risici?<\/strong>
                        \nA: Ames-test negativ ved <1 mM, men begr\u00e6nsede kromosomtestdata.<\/p>\n

                        \ud83d\udccc Forskningsbegr\u00e6nsninger<\/strong><\/h4>\n
                          \n
                        • \n

                          Begr\u00e6nsede data om kronisk eksponering<\/p>\n<\/li>\n

                        • \n

                          Ukendte effekter p\u00e5 neuroplasticitet<\/p>\n<\/li>\n

                        • \n

                          Variabel interspecies metabolisme<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Konklusion for forskere<\/strong><\/h4>\n

                          Escalinhydrochlorid tilbyder v\u00e6rdifulde muligheder for sammenlignende serotoninforskning med en unik kombination af stabilitet og lang levetid. Hydrochloridformen garanterer fremragende opl\u00f8selighed til laboratorieanvendelser.<\/p>\n

                          Vigtig ansvarsfraskrivelse: Dette produkt er udelukkende beregnet til videnskabelig forskning i akkrediterede laboratorier. Ikke til menneskelig brug eller diagnostiske anvendelser. Alle eksperimenter skal udf\u00f8res i overensstemmelse med lokale regler og etiske retningslinjer.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochlorid egenskaber<\/span><\/h3>\n

                          Synonym:<\/strong> 3,5-dimethoxy-4-ethoxyphenethylaminhydrochlorid
                          \nCAS-nummer:<\/strong> 39201-82-6
                          \nFormel:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyphenyl}ethan-1-aminhydrochlorid
                          \nMol\u00e6r masse:<\/strong> 261,8 g\/mol
                          \nRenhed:<\/strong> >97%<\/p>","protected":false},"featured_media":20228,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/media\/20228"}],"wp:attachment":[{"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalhub.com\/da\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}