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Proscaline Fumarate – Scientific Product Documentation

🔬المواصفات الكيميائية

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

المعلمات الأساسية:

• اسم الاتحاد الدولي للكيمياء البحتة والتطبيقية : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• الصيغة الجزيئية : C₁₃H₂₁NO₃ · C₄H₄O₄

• الوزن الجزيئي : 339.36 g/mol

• نقاء : ≥98% (HPLC-UV at 254 nm)

• استمارة : White crystalline powder

• Melting point : 172-174°C (decomposes)

• الذوبانية : 15 ملغ/مل في الماء، 30 ملغ/مل في الإيثانول الدافئ

🧫تطبيقات البحث

1. دراسات ربط المستقبلات :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. تحليل المسار الأيضي :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. البيانات السمية :

   • LD₅₀ (الجرذان، عن طريق الفم): 320 ملغ/كغ

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. طيف الآثار الجانبية :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. التفاعلات الحرجة :

   • خطير : MAO inhibitors, sympathomimetics

   • محفوف بالمخاطر : Serotonergic agents, vasopressors

📉بيانات الاستقرار

• مدة الصلاحية : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• طيف الكتلة : [M+H]⁺ 240.2 m/z

• UV absorption : λmax 282 نانومتر (ε = 4200)

❓Research-oriented FAQ

س1: ما هي آلية العمل؟
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌قيود البحث

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.